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KMID : 1138720110370020017
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Korean Public Health Research
2011 Volume.37 No. 2 p.17 ~ p.30
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The Study of Mechanism on the Regulation of Obesity and Health Promotion by Swimming in Postmenopausal Women: In Vivo Research on Lipid Metabolism by Swimming in Female Ovariectomized Mice
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Jeong Sun-Hyo
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Abstract
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Objectives : The purpose of this study was to investigate whether swimming regulates menopause-induced
obesity through the regulation of genes involved in lipid metabolism(: lipolysis, lipogensis and adipogenesis) in female ovariectomized mice, an animal model of postmenopausal women.
Methods : For all experiments, eight-week-old female mice(C57BL/6J) were ovariectomized(OVX) and each randomly divided into two groups (a non-swim control group and a swim group, n=8/group). Mice in swim group swam for 2 h daily for 6 weeks in a 35±1℃ water bath. All the animals received a high fat diet(45% kcal fat) for 6 weeks. To elucidate the mechanism, reverse transcription-polymerase chain reaction were performed using white adipose tissue.
Results : Swim-trained mice had significantly decreased body weight, adipose tissue weights and serum glucose levels compared with sedentary control mice. Concomitantly, swimming significantly increased mRNA levels of peroxisome proliferator-activated receptor α(PPARα) target genes responsible for fatty acid β-oxidation, such as carnitine palmitoyltransgerase-1 and thiolase in the white adipose tissue. However, mice exercised by 6-weeks swimming had decreased the mRNA expression of lipogenic genes, such as sterol regulatory elementbinding protein-1C(SREBP-1C) and fatty acid synthase compared with sedentary control mice, with decreases PPARγ target genes involved in adipogenesis, such as adipocyte fatty acid binding protein and leptin.
Conclusion : These results suggest that swimming can effectively prevent obesity caused by ovariectomy, in
part through activation of PPARα and PPARγ as well as SREBP-1C in white adipose tissue of female obese OVX mice. Moreover, these results suggest that swimming maybe contribute to the alleviation of metabolic syndrome, including obesity and hyperlipidemia, in postmenopausal women, in part through the regulation of genes involved in lipid metabolism. [Supported by grant No. KRF-2009-351-G00135 from Korea Research Foundation]
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KEYWORD
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Swimming, Postmenopausal women, Obesity, Lipid metabolism, PPAR, SREBP-1C
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